Eskandarpour M., Chen Y.H., Nunn M.A., Coupland S.E., Weston-Davies W., Calder V.L. (2020) Leukotriene B 4 and Its Receptor in Experimental Autoimmune Uveitis and in Human Retinal Tissues: Clinical Severity and LTB 4 Dependence of Retinal Th17 Cells. Am. J. Pathol. [Online ahead of print]
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Brandl F., Busslinger S., Zangemeister-Wittke U., Plückthun A. (2020) Optimizing the anti-tumor efficacy of protein-drug conjugates by engineering the molecular size and half-life. J. Control Release 327, 86-197.
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Somayeh Mazaheri S., Talebkhan Y., Mahboudi F., Nematollahi L., Cohan R.A., Ardakani E.M., Bayat E., Sabzalinejad M., Sardari S., Torkashvand F. (2020) Improvement of Certolizumab Fab’ properties by PASylation technology. Sci. Rep. 10:18464.
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Escher B., Köhler A., Job L., Worek F., Skerra A. (2020) Translating the Concept of bispecific antibodies to engineering heterodimeric phosphotriesterases with broad organophosphate substrate recognition. Biochemistry 59, 4395-4406.
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Peplau E., De Rose F., Reder S., Mittelhaeuser M., Scafetta G., Schwaiger M., Weber W.A., Bartolazzi A., Skerra A., D’Alessandria C. (2020) Development of a chimeric Fab directed against human galectin-3 and validation as an immune-PET tracer for the sensitive in vivo imaging of thyroid cancer. Thyroid 30, 1314-1326.
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Bourdeaux F., Kopp Y., Lautenschläger J., Gößner I., Besir H., Vabulas R.M. and Grininger M. (2020) Dodecin as carrier protein for immunizations and bioengineering applications. Sci. Rep. 10:13297.
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Tesarova B., Dostalova S., Smidova V., Goliasova Z., Skubalova Z., Michalkova H., Hynek D., Michalek P., Polanska H., Vaculovicova M., Hacek J., Eckschlager T., Stiborova M., Pires .S., Neves A.R.M., Abrantes A.M., Rodrigues T., Matafomei P., Botelhog M.F., Teixeira P., Mendes F., Heger Z. (2020) Surface-PASylation of ferritin to form stealth nanovehicles enhances in vivo therapeutic performance of encapsulated ellipticine. Applied Materials Today 18, 100501.
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Shamloo A., Rostami P., Mahmoudi A. (2020) PASylation enhances the stability, potency and plasma half-life of interferon α-2a: a molecular dynamics simulation. Biotechnol. J. 15:e1900385
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Deuschle F.C., Morath V., Schiefner A., Brandt C., Ballke S., Reder S., Steiger K., Schwaiger M., Weber W., Skerra A.(2020) Development of a high affinity Anticalin® directed against human CD98hc for theranostic applications. Theranostics 10, 2172-2187.
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Eggenstein E., Richter A., Skerra A. (2020). FluoroCalins: engineered lipocalins with novel binding functions fused to a fluorescent protein for applications in biomolecular imaging and detection. Protein Eng. Des. Sel. 32, 289-296.
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Brandl F., Merten H., Zimmermann M., Béhé M., Zangemeister-Wittke U., Plückthun A. (2019). Influence of size and charge of unstructured polypeptides on pharmacokinetics and biodistribution of targeted fusion proteins. J. Control. Release 307, 379-392.
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Sezin T., Murthy S., Attah C., Seutter M., Holtsche M.M., Hammers C.M., Schmidt E., Meshrkey F., Mousavi S., Zillikens D., Nunn M.A., Sadik C.D. (2019) Dual inhibition of complement factor 5 and leukotriene B4 synergistically suppresses murine pemphigoid disease. JCI Insight 4, e128239.
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Krishnamurthy S., Muthukumaran P., Jayakumar M.K.G., Lisse D., Masurkar N.D., Xu C., Chan J.M., Drum C.L. (2019) Surface protein engineering increases the circulation time of a cell membrane-based nanotherapeutic. Nanomedicine 18, 169-178.
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Aghaabdollahian S., Ahangari Cohan R., Norouzian D., Davami F., Asadi Karam M.R., Torkashvand F., Vaseghi G., Moazzami R., Latif Dizaji S. (2019) Enhancing bioactivity, physicochemical, and pharmacokinetic properties of a nano-sized, anti-VEGFR2 Adnectin, through PASylation technology. Sci. Rep. 9, 2978.
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Khodabakhsh F., Norouzian D., Vaziri B., Ahangari Cohan R., Sardari S., Mahboudi F., Behdani M., Mansouri K., Mehdizadeh A. (2018) Development of a novel nano-sized anti-VEGFA nanobody with enhanced physicochemical and pharmacokinetic properties. Artif. Cells Nanomed Biotechnol. 46, 1402-1414.
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Hoffmann K., Milech N., Juraja S.M., Cunningham P.T., Stone S.R., Francis R.W., Anastasas M., Hall C.M., Heinrich T., Bogdawa H.M., Winslow S., Scobie M.N., Dewhurst R.E., Florez L., Ong F., Kerfoot M., Champain D., Adams A.M., Fletcher S., Viola H.M., Hool L.C., Connor T., Longville B.A.C., Tan Y.F., Kroeger K., Morath V., Weiss G.A., Skerra A., Hopkins R.M., Watt P.M. (2018) A platform for discovery of functional cell-penetrating peptides for efficient multi-cargo intracellular delivery. Sci. Rep. 8, 12538.
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Friedrich L., Kornberger P., Mendler C.T., Multhoff G., Schwaiger M., Skerra A. (2018) Selection of an Anticalin® against the membrane form of Hsp70 via bacterial surface display and its theranostic application in tumour models. Biol. Chem. 14, 235-252.
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Ahmadpour S., Hosseinimehr S. J. (2018) PASylation as a powerful technology for improving the pharmacokinetic properties of biopharmaceuticals. Curr. Drug Deliv. 15, 331-341.
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Zvonova E. A., Ershov A. V., Ershova O.A., Sudomoina M. A., Degterev M. B., Poroshin G. N., Eremeev A. V., Karpov A. P., Vishnevsky A. Y., Goldenkova-Pavlova I. V., Petrov A. V., Ruchko S. V., Shuster A. M. (2017) PASylation technology improves recombinant interferon-β1b solubility, stability, and biological activity. Appl. Microbiol. Biotechnol. 101, 1975-1987.
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Hedayati M. H., Norouzian D., Aminian M., Teimourian S., Ahangari Cohan R., Sardari S., Khorramizadeh M. R. (2017) Molecular design, expression and evaluation of PASylated human recombinant erythropoietin with enhanced functional properties. Protein J.
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Harder M. J., Kuhn N., Schrezenmeier H., Höchsmann B., von Zabern I., Weinstock C., Simmet T., Ricklin D., Lambris J. D., Skerra A., Anliker M., Schmidt C. Q. (2016) Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation. Blood
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Zelikin A.N., Ehrhardt C. and Healy A.M. (2016) Materials and methods for delivery of biological drugs. Nat. Chem. 8, 997-1007.
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Lerchner A., Daake M., Jarasch A., Skerra A. (2016) Fusion of an alcohol dehydrogenase with an aminotransferase using a PAS linker to improve coupled enzymatic alcohol-to-amine conversion. Protein Eng. Des. Sel. 29, 557-562.
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Mendler C. T., Feuchtinger A., Heid I., Aichler M., D’Alessandria C., Pirsig S., Blechert B., Wester H. J., Braren R., Walch A., Skerra A., Schwaiger M. (2016) Tumor uptake of anti-CD20 Fabs depends on tumor perfusion. J. Nucl. Med. 57, 1971-1977.
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Chhabra K. H., Adams J. M., Jones G. L. , Yamashita M., Schlapschy M., Skerra A., Rubinstein M. and Low M. J. (2016) Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity.
Mol. Metab. 5, 869–881.
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Bolze F., Bast A., Mocek S., Morath V., Yuan D., Rink N., Schlapschy M., Zimmermann A., Heikenwalder M., Skerra A., Klingenspor M. (2016) Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation. Diabetologia 59, 2005-2012.
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Fracasso G., Falvo E., Colotti G., Fazi F., Ingegnere T., Amalfitano A., Doglietto G.B., Alfieri S., Boffi A., Morea V., Conti G., Tremante E., Giacomini P., Arcovito A., Ceci P. (2016) Selective delivery of doxorubicin by novel stimuli-sensitive nano-ferritins overcomes tumor refractoriness. J. Control. Release 239, 10-18.
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Falvo E., Tremante E., Arcovito A., Papi M., Elad N., Boffi A., Morea V., Conti G., Toffoli G., Fracasso G., Giacomini P., Ceci P. (2016) Improved doxorubicin encapsulation and pharmacokinetics of ferritin-fusion protein nanocarriers bearing proline, serine, and alanine elements. Biomacromolecules 17, 514-522.
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