Schilz J., Binder U., Friedrich L., Gebauer M., Lutz C., Schlapschy M., Schiefner A., Skerra A. (2021) Molecular recognition of structurally disordered Pro/Ala-rich sequences (PAS) by antibodies involves an Ala residue at the hot spot of the epitope. J. Mol. Biol. 433, 167113.

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Binder U., Skerra A. (2020) PASylated Thymosin α1: a long-acting immunostimulatory peptide for applications in oncology and virology. Int. J. Mol. Sci. 22, E124.

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Schiefner A., Walser R., Gebauer M., Skerra A. (2020) Proline/alanine-rich sequence (PAS) polypeptides as an alternative to PEG precipitants for protein crystallization. Acta Cryst. F76, 320-325.

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Richter A., Knorr K., Schlapschy M., Robu S., Morath V., Mendler C., Yen H., Steiger K., Kiechle M., Weber W., Skerra A., Schwaiger M. (2020) First in-human medical imaging with a PASylated 89Zr-labeled anti-HER2 Fab-fragment in a patient with metastatic breast cancer. Nucl. Med. Mol. Imaging 54, 114–119.

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Powers N. E., Swartzwelter B., Marchetti C., de Graaf D. M., Lerchner A., Schlapschy M., Datar R., Binder U., Edwards C. K. 3rd, Skerra A., Dinarello C. A. (2019) PASylation of IL-1 Receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis. J. Biol. Chem. 295, 868 –882.

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Griffiths K., Binder U., McDowell W., Tommasi R., Frigerio M., Darby W.G., Hosking C.G., Renaud L., Machacek M., Lloyd P., Skerra A., Foley M. (2019) Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4. MAbs 11, 1331-1340.
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Längin M., Mayr T., Reichart B., Michel S., Buchholz S., Guethoff S., Dashkevich A., Baehr A., Egerer S., Bauer A., Mihalj M., Panelli A., Issl L., Ying J., Fresch A.K., Buttgereit I., Mokelke M., Radan J., Werner F., Lutzmann I., Steen S., Sjöberg T., Paskevicius A., Qiuming L., Sfriso R., Rieben R., Dahlhoff M., Kessler B., Kemter E., Klett K., Hinkel R., Kupatt C., Falkenau A., Reu S., Ellgass R., Herzog R., Binder U., Wich G., Skerra A., Ayares D., Kind A., Schönmann U., Kaup F.J., Hagl C., Wolf E., Klymiuk N., Brenner P., Abicht J.M. (2018) Consistent success in life-supporting porcine cardiac xenotransplantation. Nature 564, 430-433.

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Xia Y., Schlapschy M., Morath V., Roeder N., Vogt E.I., Stadler D., Cheng X., Dittmer U., Sutter K., Heikenwalder M., Skerra A., Protzer U. (2018) PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice. Antiviral Res. 161, 134-143.

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Nganou-Makamdop K., Billingsley J.M., Yaffe Z., O’Connor G., Tharp G.K., Ransier A., Laboune F., Matus-Nicodemos R., Lerner A., Gharu L., Robertson J.M., Ford M.L., Schlapschy M., Kuhn N., Lensch A., Lifson J., Nason M., Skerra A., Schreiber G., Bosinger S.E., Douek D.C. (2018) Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication. PLoS Pathog. 14, e1007246.

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Gebauer M. & Skerra A. (2018) Prospects of PASylation® for the design of protein and peptide therapeutics with extended half-life and enhanced action. Bioorg. Med. Chem. 26, 2882-2887.

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Griffiths K., Habiel D. M., Jaffar J., Binder U., Darby W. G., Hosking C. G., Skerra A., Westall G. P., Hogaboam C. M., Foley M. (2018) Anti-fibrotic effects of CXCR4-targeting i-body AD-114 in preclinical models of pulmonary fibrosis. Sci. Rep. 8, 3212.

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Breibeck J. & Skerra A. (2018) The polypeptide biophysics of proline/alanine-rich sequences (PAS): Recombinant biopolymers with PEG-like properties. Biopolymers 108, e23069.

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Binder U. & Skerra A. (2017) PASylation®: A versatile technology to extend drug delivery. Curr. Opin. Colloid Int. 31, 10-17.

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Kuhn N., Schmidt C. Q., Schlapschy M., Skerra A. (2016) PASylated Coversin, a C5-specific complement inhibitor with extended pharmacokinetics, shows enhanced anti-hemolytic activity in vitro. Bioconjug. Chem. 27, 2359-2371.

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Bolze F., Morath V., Bast A., Rink N., Schlapschy M., Mocek S., Skerra A., Klingenspor M. (2015) Long-acting PASylated leptin ameliorates obesity by promoting satiety and preventing hypometabolism in leptin-deficient Lepob/obmice. Endocrinology 157, 233–244.

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Morath V., Bolze F., Schlapschy M., Schneider S., Sedlmayer F., Seyfarth K., Klingenspor M., Skerra A. (2015) PASylation of murine leptin leads to extended plasma half-life and enhanced in vivo efficacy. Mol. Pharmaceutics 12, 1431–1442.

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Mendler C. T., Friedrich L., Laitinen I., Schlapschy M., Schwaiger M., Wester H.J., Skerra A. (2015) High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation. MAbs 7, 96-109.

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Harari D., Kuhn N., Abramovich R., Sasson K., Zozulya AL., Smith P., Schlapschy M., Aharoni R., Köster M., Eilam R., Skerra A., Schreiber G. (2014) Enhanced in vivo efficacy of a type I interferon superagonist with extended plasma half-life in a mouse model of multiple sclerosis. J. Biol. Chem. 289, 29014-29029.

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Di Cesare S., Binder U., Maier T., Skerra A. (2013) High-yield production of PASylated human growth hormone using secretory E. coli technology. BioProcess Int. 11, 30–38.

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Schlapschy M., Binder U., Börger C., Theobald I., Wachinger K., Kisling S., Haller D., Skerra A. (2013) PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins. Protein Eng. Des. Sel. 26, 489-501.

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