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XL-protein offers PASylation, a biological alternative to PEGylation
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Iodoacety-PAS(200)
PAS200 polypeptide

PAS(200) polymer

From: 800,00 €

excl. VAT plus Shipping Costs

Key features

• Biodegradable PEG alternative to expand the hydrodymanic volume of a drug
• Suitable for plasma half-life extension
• Unstructured, uncharged & hydrophilic polypeptide
• Recombinantly expressed in E. coli
• Length: 201 amino acids
• Available as unmodified or iodoacetyl functionalized PAS polymer

Delivery time: 4 to 7 business days

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SKU: N/A Category: PAS polypeptides
  • Description
  • Additional information

Description

PASylation, the drug conjugation with unstructured, uncharged and highly hydrophilic PAS polypeptides, increases the hydrodynamic volume of the drug above the kidney pore size, slowing down kidney filtration. PASylation allows fine-tuning of pharmacokinetics by variation of the PAS polypeptide length. Available as unmodified or iodoacetyl functionalized proline/alanine-rich sequence (PAS) polymer.

Iodoacetyl-PAS(200) reacts with free thiol groups on biomolecules. The iodine group will be replaced by the thiol group of the drug to form a stable carbon thiol bond.

This product is only available for commercial customers or academic research labs.

Literature
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Derivatives & customization

Commercial licenses, larger amounts and customized linker chemistry or chain lengths are avaible upon request.

Request a quote

Additional information

Source

Expressed in E. coli

Product size

10 mg, 4 mg, 5 mg, 1 mg

Form

Lyophilized

Restrictions

For Research Use only

Modification

Iodoacetyl-PAS(200), Unmodified PAS polymer

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