PASylation, the drug conjugation with unstructured, uncharged and highly hydrophilic PAS polypeptides, increases the hydrodynamic volume of the drug above the kidney pore size, slowing down kidney filtration. PASylation allows fine-tuning of pharmacokinetics by variation of the PAS polypeptide length. Available as unmodified or iodoacetyl functionalized proline/alanine-rich sequence (PAS) polymer.
Iodoacetyl-PAS(200) reacts with free thiol groups on biomolecules. The iodine group will be replaced by the thiol group of the drug to form a stable carbon thiol bond.
This product is only available for commercial customers or academic research labs.
Derivatives & customization
Commercial licenses, larger amounts and customized linker chemistry or chain lengths are avaible upon request.